Research Article

Propylene glycol, polysorbate-80 and sodium lauryl sulfate as potential dermal absorption enhancers of celecoxib

Mbah, C. J  and  Okekearu, L

Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.

*Corresponding author. Email: cjmbah123@yahoo.com

 
Received 15 February, 2013; Accepted 24 March, 2013

Abstract

The purpose of this study was to investigate propylene glycol, polysorbate-80 and sodium lauryl sulfate as potential dermal absorption enhancers of celecoxib by studying their effects on celecoxib partition coefficient. The partition coefficient was determined in chloroform-water system at room temperature. It was found that all the vehicles studied decreased the partition coefficient of celecoxib. The results suggest that propylene glycol, polysorbate-80 and sodium lauryl sulfate respectively, has the potential of decreasing the vehicle-skin partition coefficient of celecoxib and therefore are not potential vehicles for improved transdermal delivery of celecoxib.

Keywords:  Celecoxib, partition coefficient, spectrophotometry.