Research article

Isolation of carvacol from Origanum vulgare, synthesis of some organosilicon derivatives, and investigating of its antioxidant, antibacterial activities

*Galehassadi M, Rezaii E, Najavand S, Mahkam M and Mohammadzadeh Gheshlaghi N

Department of Chemistry, Azarbaijan Shahid Madani University, Tabriz, Iran

*Corresponding Author E-mail: mg-assadi@azaruniv.edu, mgalehassadi@yahoo.com

Accepted 17 September 2014

Abstract

Isolation of carvacol from Organum was done by hydro distillation using sodium bicarbonate to remove phenolic compounds and then it was extracted by Heptane. Carvacol was separated by chromatographic method, identified by HPLC and common spectroscopic methods. In order to study the mechanism of its action, some organosilicon derivatives were synthesized. In this way, antioxidant, and antibacterial activities were investigated. We proposed a mechanism for its action.

Keywords: Carvacol, Organum, silyl ethers, Antibacterial, antioxidant