Research article

Exercise training reduces chronic dizziness by inhibiting NADPH oxidase

¹Ching-Hsia Hung, ²Chung-Lan Kao, ³Shih-Hung Chan and *¹Kun-Ling Tsai

¹Institute and Department of Physical Therapy, National Cheng Kung University,

Tainan, Taiwan

²Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan

³Department of Internal Medicine, National Cheng Kung University, Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan

*Corresponding Author E-mail: kunlingtsai@mail.ncku.edu.tw; Tel. +886 6 2353535#6219; Fax: +886 6 2370411.

Accepted 23 December 2014

Abstract

Dizziness is a one of the common clinical symptoms noted in internal medicine clinics. Recent studies suggested that patients with dizziness receive a high level of oxidative stress. However, the probable mechanism of this finding is still largely unknown. In fact, exercise has been proven to bean efficient non-pharmacological approach for improving good health in humans. Previous studies revealed that exercise cures dizziness and reduces the circulatory oxidative stress in patients with chronic dizziness. In this study, we confirmed that the exercise intervention inhibits the NADPH oxidase activation through gp91 and p22 mRNA repression. We also reported that the exercise intervention promotes Hemo oxygenase-1 (HMOX-1), an antioxidant gene, expression level by using the real-time PCR assay. Our results demonstrated that exercise cures chronic dizziness through NADPH oxidase inhibition and HMOX-1 activation.

Keywords: exercise, chronic dizziness, NADPH oxidase, HMOX-1